在动脉粥样硬化饮食引起的动脉粥样硬化中,源自类黄酮的富含类黄酮的富含类黄酮的含量。
摘要来源:
comb comb comb chem Chem高吞吐量筛查。 2023年10月2日。epub 2023 10月2日。pmid: 37807415 Sharma, Yongchao Liu, Xiaoying Wang, Ritu Kainth, Deepika Kumari
Article Affiliation:Xiuping Wang
Abstract:BACKGROUND: Portulaca grandiflora is a tiny, upright herb that contains a variety of chemical components, including生物碱,糖苷,粘液,蛋白质,单宁,类黄酮,皂苷,多糖和具有可能有助于动脉粥样硬化的特性的三萜类化合物。 Portulaca Grandiflora的药理学特性是抗氧化剂,抗糖尿病,抗肌,抗菌,抗菌和抗激素弹药属性。
目标: 甲醇提取物的产量高于乙醇和丙酮的产率,以及其植物构成剂的产量,其植物构醇(如植物生态),例如Flavonoids和polyphenols,and polyphenols,and polyphenols,and pothio antio antioxident poltent antioxidents poltent antioxidant poltents poltent antioxidants。 In order to determine the effectiveness ofPortulaca grandiflora methanol extract fraction against high-fat diet (HFD)-induced hyperlipidemia, hemodynamic change, antioxidant levels, and vascular dysfunction in rats, a study was carried out on a flavonoid-rich methanol extract fraction of the aerial part of Portulaca grandiflora Hook.
方法: 该方法涉及30天的研究,涉及雄性Wistar大鼠(240-250 g)(n = 5),这些大鼠(n = 5)均以ATH饮食喂食。研究组分为(i)对照组,(ii)疾病对照组,(iii)疾病 +标准药物(Atorvastatin 20mg/kg,口服,(IV)疾病 +测试提取物剂量1(portulaca grandiflora 200mg/kg)口服)和(v)疾病 +测试提取剂量2(gressulaca grandiflora 400mg/kg)。 Both the test drug Portulaca grandiflora and the standard drug Atorvastatin were given orally for 30 days.
RESULTS: At the end of the study, blood samples were taken to measure the serum lipid profile, alanine aminotransferase, aspartate aminotransferase, lactate脱氢酶和氧化组织应激水平。进行血液动力学参数和主动脉染色。 Portulaca Grandiflora治疗改善了脂质谱,并大大降低了氧化应激水平。主动脉染色检查表明,动脉粥样硬化病变显着减少。
结论: