长期增强诱导的损害对于微波暴露后的空间记忆破坏至关重要。
摘要来源:
int J radiat Biol。 2013年12月; 89(12):1100-7。 EPUB 2013年7月24日。PMID: 23786183 23786183 Zhou, Shuiming Wang, Yabing Gao, Lifeng Wang, Zheng Yong, Hongyan Zuo, Li Zhao, Ji Dong, Xinping Xu, Zhentao Su
Article Affiliation:Hui Wang
Abstract:PURPOSE: To assess the impact of在学习和记忆中的微波暴露并探索基本机制。
材料和方法: wistar大鼠被暴露于2.856 GHz脉冲场的平均电力密度在0 mw/mw/cm(2),5 mw/cmw/c.2) MW/cm(2)和50 mW/cm(2)持续6分钟。空间记忆是驴子SED由Morris Water Maze(MWM)任务。微波暴露后不久就进行了一项体内研究,以评估内侧穿孔路径(MPP)dentate Gyrus(DG)途径中长期增强(LTP)的种群峰值(PS)的变化。 The structure of the hippocampus was observed by the light microscopy and the transmission electron microscopy (TEM) at 7 d after microwave exposure.
RESULTS: Our results showed that the rats exposed in 10 mW/cm(2) and 50 mW/cm(2) microwave displayed significant deficits in spatial learning在暴露后6小时,1 d和3 d时记忆。在10 mW/cm(2)和50 mW/cm(2)微波暴露后也发现了PS幅度降低。此外,在暴露于10 mW/cm(2)和50 mW/cm(2)微波的大鼠中观察到海马神经元的变性程度,突触囊泡降低和突触裂的模糊。与假手术组相比,大鼠暴露在5 mW/cm(2) microwave showed no difference in the above experiments.
CONCLUSIONS: This study suggested that impairment of LTP induction and the damages of hippocampal structure, especially changes of synapses, might contribute to cognitive impairment after microwave曝光。