抗药性训练和二维加尿布疗法提高了神经营养蛋白水平，并通过增加大鼠海马的年龄来提高认知功能。
摘要来源：
生物化药物。 2022年6月20日； 153：113306。 EPUB 2022 6月20日。PMID： 35738179 35738179 Wenqing Xie, Guang Yang, Hongfu Jin, Hengzhen Li, Farzaneh Chehelcheraghi, Yusheng Li
Article Affiliation:Masoud Rahmati
Abstract:INTRODUCTION: Inflammation and oxidative stress are two major factors in accelerating brain衰老。消费一些具有抗氧化剂和抗炎特性的传统草药，例如二奥提取物（UD）和耐药训练（RT），可以有效控制早熟和记忆力障碍。因此，我们假设RT和UD可能在预防记忆障碍和海马组织的变化中起着至关重要的作用。将RT组训练五周，并在0.0166 W/V浓度（50 mg/kg，口服/每日）中进行UD提取物。 We also examined the effects of RT and Ud on the behavioral (memory and learning), histological (the morphological changes in thedentate gyrus), and transcript aspects of hippocampal tissue.
RESULTS: Aging led to karyopyknosis in the hippocampal tissue, which was alleviated by RT and UD补充。 RT和UD伴随着GPX，GSH，GAP-43的增加，并且海马中的CAP-1水平降低。此外，RT和UD导致NGF，BDNF和GAP-43水平增加，MDA降低，并保护海马核肿瘤的Al组织，与认知改善有关。 However, these interventions had no significant effect on the hippocampal levels of IL-1β, SOD, and CAT.
CONCLUSIONS: These findings suggest that increasing age decreases hippocampal NGF, BDNF, and GAP-43 levels and impairs cognition, which may be reversed by regular RT and UD提取物。