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Abstract Title:Cannabis-induced Moto-Cognitive Dysfunction in Wistar Rats: Ameliorative Efficacy Nigella sativa。
摘要来源：
马来人J Med Sci。 2016年9月; 23（5）：17-28。 EPUB 2016年10月5日。PMID： 279044421 27904421 Abdulbasit Amin，Wahab Imam Abdulmajeed，Abdulmumin Ibrahim，Olayemi Joseph Olajide，Musa Iyiola Ajibola，Abdulmusawir Alli-Oluwafuyi class =“ sub_abstract_label”>背景： 大麻是一种广泛使用的非法药物，具有各种人格综合征的威胁，而nigella sativa已被广泛牵连为在许多神经疾病中具有治疗功效。 PRESENT研究调查了Nigella sativa油（NSO）对大麻诱导的Moto-Cognitables的改善功效。
方法： spans> scopolamine（ scopolamine（1 mg/kg I.p.） Mg/kg）诱导的认知障碍，然后连续14天口服NSO（1 mL/kg）。 Morris Water Maze（MWM）范式用于评估记忆指数，升高的迷宫用于焦虑般的行为，并将开放式测试用于运动活动。 thereafter, the rats were sacrificed and their brains were removed for histopathologic studies.
RESULTS: Cannabis-like Scopolamine caused memory impairment, delayed latency in the MWM, and anxiety-like behaviour, coupled with alterations in the cerebello-hippocampal neurons. NSO减轻大麻引起的认知的大鼠治疗后治疗dysfunction as with scopolamine and impaired anxiety-like behaviour by increasing open arm entry, line crossing, and histological changes.
CONCLUSIONS: The observed ameliorative effects of NSO make it a promising agent against moto-cognitive dysfunction and cerebelo-hippocampal alterations induced by大麻。