鳄鱼对毒性诱导的脱髓鞘模型的认知,平衡和疼痛的影响。
摘要来源:
acta Neurol taiwan。 2024年6月30日; 33(2):48-59。 PMID: 37848220“ Farbod, Roya Beygtashkhani
Article Affiliation:Rouholah Fatemi
Abstract:OBJECTIVE: The purpose of this study was to investigate the effects of Crocin on brain neuroterophins, cognition, sensory and motor dysfunction and compare to fingolimod effects in在雌性Wistar大鼠中用溴化乙醚EB进行有毒引起的脱髓鞘。
方法: 动物被分为8组;假手术(Sham)操作(商店),EAE,鳄鱼处理,车辆,fingolompd(手指)和fingolimod + crocin(Cr + Fing)。 Demyeli单剂量注射10μl的EB 0.1%是在大脑的第四个心室中诱导的。每天施用鳄鱼和芬诺莫德21天,口服烤肉。 BDNF, NGF1, tail flake latency, balance and behavioral variables were sampled and analyzed by paired t-test and ANOVA test with repeated post hoc measurements.
RESULTS: The results showed that crocin improves all studied factors, but remarkable improvements were observed in dosage of 10 mg/kg。在开放野外测试,感觉和运动神经传导速度,尾部弹性潜伏期和临床分数(P小于005)中,鳄鱼(10mg/kg)和芬诺莫德(1mg/kg)显着改善了认知变量。此外,与芬洛莫德共同应用鳄鱼蛋白会导致所有评估因素的显着增加,大于鳄鱼或fingolimod干预。