pH敏感的槲皮素纳米颗粒通过结肠特异性递送改善小鼠DSS诱导的结肠炎。
摘要来源：
mol Nutr Food Res。 2023年11月27日：E2300051。 EPUB 2023 11月27日。PMID： 38010348“> 38010348 Jingjie Liang, Wenqing Xue, Haitao Hu, Jing Meng, Min Zhang
Article Affiliation:Lechen Wang
Abstract:SCOPE: Ulcerative colitis (UC) is a classic inflammatory bowel disease (IBD) that represents a serious threat to human 健康。作为具有多种生物学活性的天然类黄酮，槲皮素（QCT）因化学稳定性的限制而遭受了低生物利用度的损失。在这里，该研究研究了槲皮素纳米颗粒（QCT NP）对硫酸葡萄酸钠（DSS）诱导结肠炎小鼠的调节作用。
METHODS AND RESULTS: Chitosan is modified to obtain N-succinyl chitosan (NSC) with superior water solubility. Nanoparticles composed of sodium alginate (SA) and NSC can encapsulate QCT after cross-linking, forming QCT NPs. In vitro drug release assays demonstrate the pH sensitivity of QCT NPs. Compared with free quercetin, QCT NPs have better therapeutic efficacy in modulating gut microbiota and its metabolites short chain fatty acid (SCFAs) to relieve DSS-induced colitis in mice, thereby alleviating colon inflammatory infiltration, increasing goblet cells density and mucus protein, ameliorating TNF-α, IL-1β, IL-6, IL-10, and Myeloperoxidase (MPO) levels, and recovering intestinal barrier integrity.
CONCLUSION: pH sensitive QCT nanoparticles can reduce inflammatory reaction, improve gut microbiota, and repair intestinal barrier by targeting colon, thus improving DSS induced colitis in mice, providing参考结肠炎的参考。