foeniculum vulgare精油通过抑制NF-KB途径来改善大鼠乙酸引起的结肠炎。
摘要来源:
炎症药理学。 2017年10月24日。EPUB 2017年10月24日。PMID: 29067571 29067571 Ahmad-Reza Dehpour,Saeed Mohammadi Motamed,Maryam Yazdanparast,Mohsen Chamanara,Mousa Sahebgharani,Amir Rashidian
文章隶属关系:
seyed mahdi rezayat rezayat rezayat rezayat
摘要: of the present study is to investigate the protective effects of Foeniculum vulgare essential oil on intestinal inflammation through the inhibition of NF-kB pathway in acetic acid-induced rat colitis.METHODS: Acute colitis was induced by intra-rectal administration of 2 mL of diluted acetic acid (4%)解决方案。两个h诱导结肠炎后,我们的盐水,正常盐水,地塞米松(2 mg/kg)和F. vulgare精油(100、200、400 mg/kg)的诱导后,我们通过口服粘液剂并继续连续5天对动物施用。对宏观和微观病变进行了评估。通过生化方法评估MPO活性。 Furthermore, TNF-α activity was detected by immunohistochemistry (IHC) and the expression level of p-NF-kB p65 protein was measured by western blot analysis.
RESULTS: Dexamethasone and F. vulgare essential oil (200, 400 mg/kg) reduced the与乙酸基团相比,宏观和微观病变(p <0.01,p <0.001)。另外,与乙酸基团相比,这些药物降低了MPO的活性(P <0.01,P <0.001)和结肠组织中TNF-α阳性细胞的表达(P <0.05,P <0.01,P <0.001)。此外,它们抑制了乙酸诱导的P-N表达F-kb p65蛋白(p <0.05,p <0.001)。
结论: