摘要来源： Nutr res实践。 2018年4月； 12（2）：101-109。 EPUB 2018 3月22日。PMID： 29629026“> 29629026 Kim, Eunju Kim, Jae-Ho Shin, Pu Reum Seok, Moon Jea Woo, Yuri Kim Hee-Jin Jeon BACKGROUND/OBJECTIVES: The objective of this study was to investigate the effects of vitamin C on inflammation, tumor development, and甲氧甲烷（AOM）/葡萄酸硫酸钠（DSS）诱导的炎症相关的早期结肠癌MOUSE模型。 材料/方法： 雄性balb/c小鼠在腹膜内注射AOM [10 mg/kg体重（b.w）]，并给出了两个7-d cycles and a in of [10 mg/kg体重（b.w）]，并给出了两个7-d cycles a 2％ds cycles a 14 d in Inter-1 ds Intercy Intercle in Intercle in Intercy Intercle in Interclece。 Vitamin C (60 mg/kg b.w. and 120 mg/kg b.w.) was supplemented by gavage for 5 weeks starting 2 d after the AOM injection. RESULTS: The vitamin C treatment suppressed inflammatory morbidity, as reflected by disease activity index (DAI) in recovery phase and inhibited结肠的缩短，减少组织学损害。此外，补充维生素C抑制了促炎性介质和细胞因子的mRNA水平，包括环氧酶-2，微粒细胞前列腺素E合酶-2，肿瘤坏死因子-α，白介素，白细胞介素，以及降低的细胞核抗原抗生物抗生物的表达，并降低。阿尔多ugh the microbial composition did not differ significantly between the groups, administration of vitamin C improved the level of inflammation-relatedandto control levels. CONCLUSION: Vitamin C treatment provided moderate suppression of inflammation, proliferation, and certain inflammation-related dysbiosis in a murine model of colitis相关的与结肠癌相关。这些发现支持补充维生素C可以使结肠健康有益。必须使用各种剂量的维生素C的长期临床研究。