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Abstract Title:Thymoquinone enhances the antioxidant and anticancer activity of Lebanese蜂胶
摘要来源:
世界J Clin Oncol。 2023年5月24日; 14(5):203-214。 PMID: 37275937“> 37275937 Ibrahim, Maamoun Fatfat, Hala Gali-Muhtasib, Hala Khalife
Article Affiliation:Sima AlDreini
Abstract:BACKGROUND: Reactive oxygen species (ROS) are produced by multiple cellular processes and are maintained at optimal levels in normal cells by endogenous抗氧化剂。近年来,从饮食来源寻找潜在的外源抗氧化剂已引起了极大的关注,以消除与之相关的多余ROS氧化应激相关疾病在内,包括癌症。蜂胶是一种树脂蜜蜂产物,已被证明对氧化应激和抗癌作用具有保护作用。 Thymoquinone (TQ) the main constituent ofessential oil.
METHODS: Crude extracts of Lebanese propolis collected from two locations, Rashaya and Akkar-Danniyeh, were prepared in methanol and the total phenolic content was determined by Folin-Ciocalteu method.通过清除2,2-二苯基-1-羟基羟基(DPPH)自由基的能力来评估抗氧化活性,并抑制HO诱导的人红细胞氧化溶血。通过[3-(4,5-二甲基)评估抗癌活性iazol-2-基)-2,5二苯基四唑溴化物] MTT分析对HCT-116人类结直肠癌细胞和MDA-MB-231人类乳腺癌细胞。
结论: 我们的结果表明,黎巴嫩蜂窝提取物具有抗氧化剂和抗癌的潜力及其与TQ的组合可能预防ROS-介导的疾病。