金纳米颗粒通过解压缩结直肠癌血管增强顺铂递送和增强化学疗法

int j纳米医学。 2018; 13：6207-6221。 EPUB 2018年10月9日。PMID： 30349245“> 30349245”> 30349245 Wende Yang，Li Qin，Yunlong Pan

Xiaoxu zhao

背景： 肿瘤容器持续压缩肿瘤的固体压力，这些压缩是肿瘤的肿瘤内部脉冲基质的固体压力，其浓度是限量性地，限量性地渗透了限量。基质内的胶原蛋白参与将固定应力传输到肿瘤血管并限制药物输送。

Purpose: The objective of this study was to identify whether gold nanoparticles (AuNPs) were able to decompress colorectal cancer vessels and enhance vessel perfusion as well as drug delivery in colorectal cancer.

Methods: Colorectal cancer xenograft mice were treated with AuNPs or正常的盐水。癌基胶原水平，癌症灌注，肿瘤的缺氧是通过组织学检查的。显微镜。

结果： aunps能够降低大肠癌相关的成纤维细胞（CAF）的密度，以减少肿瘤stromal stromal col的产生Lagen I，并通过AKT信号通路减少纤维化信号的表达，包括CTGF，TGF-β1以及体内的VEGF和VEGF。因此，AUNP可以减轻肿瘤的固体应力，随后导致血管灌注增强。 Therefore, cisplatin as well as oxygen delivery to tumors were improved by AuNPs, which reduced hypoxia while sensitizing therapy of cisplatin in colorectal cancer model.

Conclusion: AuNPs were effective agents in enhancing cisplatin delivery and potentiating inhibiting tumor growth by减压结直肠癌血管。