appoptian colon colon colon colon colon colon in co in con in con in con in con in con in con in co in con in co in con in c.体外和体内。
抽象来源：
伊朗J基本医学科学。 2016年4月； 19（4）：358-65。 PMID： 27279978“ Najme Nikdel，Asma Mostafapour，Mohammad Amin Kerachian
文章隶属关系：Javad Baharara
摘要：
治疗应用。本研究试图评估抗癌波斯海湾海参种植的潜力Holothuria竞技场（H. Arenicola）在体外和体内的小鼠结肠癌细胞上的水提取物。
材料和方法： ct26癌细胞在24和48 hr中均与ct26癌细胞一起处理。 MTT分析和形态学观察结果。通过荧光显微镜（DNA片段化测定），流式细胞仪，caspase -3和-9比色测定法检查了凋亡效应。 The in vivo anti-tumor efficacy of sea cucumber extract on CT26 tumor cells transplanted in BALB/c mice was also investigated.
RESULTS: The results showed that the water extract of sea cucumber revealed remarkable anti-proliferative effect on CT26 tumor cells with IC50= 31μg/ml，体外募集固有凋亡途径。另外，在纯合小鼠中，经过治疗组的结肠肿瘤体积大幅降低。你好停止疗法检查阐明了海参提取物减弱了肿瘤的大小和体积以及凋亡特征。 Moreover, RT-PCR analysis revealed that sea cucumber extract induced intrinsic apoptosis in vivo through suppression of Bcl-2 expression.
CONCLUSION: Our data confirmed this notion that sea cucumber administrates anti-cancer effect that can be used as complementary in preclinical experiments, so further characterization are建议用于检测海参代谢物和临床应用。