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Abstract Title:Hyperforin Suppresses Oncogenic Kinases and Induces Apoptosis in Colorectal Cancer Cells.
Abstract Source:
体内。 2023; 37（1）：182-189。 PMID： 36593022“ Chang, Jing-Jim Ou
Article Affiliation:Li-Cho Hsu
Abstract:BACKGROUND/AIM: Signal transducer and activator of transcription 3 (STAT3), Janus Kinase 1 (JAK1), extracellular signal-regulated kinase (ERK), and protein kinase B （AKT）对于结直肠癌（CRC）的恶性转化和进展至关重要，可以被视为治疗干预措施的靶标。 hyperforin，一种来自Hypericum perforatum的活性成分据报道，抑制炎症。 However, whether hyperforin may suppress CRC progression via inactivation of JAK/STAT3, ERK or AKT signaling remains unclear.
MATERIALS AND METHODS: Human CRC cells were used to identify the treatment efficacy of hyperforin and its underlying mechanisms of action by MTT, flow cytometry, wound healing,和Western印迹分析。
结果： hyperforin不仅引起细胞毒性，外部/内在凋亡信号传导，而且抑制了CRC的入侵/迁移能力。 The phosphorylation of STAT3, JAK1, ERK and AKT was found to be decreased by hyperforin.
CONCLUSION: Hyperforin inactivates multiple oncogenic kinases and induces apoptosis signaling in CRC cells.