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Abstract Title:Luteolin ameliorates loperamide-induced functional constipation in mice.
Abstract来源：
Braz J Med Biol Res。 2023; 56：e12466。 EPUB 2023 1月27日。PMID： 36722660 Wang, Huiping Gan, Xinchun Xiao, Liangwu Huang, Wenxin Li, Zongrun Li
Article Affiliation:Yujin Wang
Abstract:Functional constipation (FC) is one of the most common gastrointestinal disorders characterized by hard stools and infrequent bowel movements, which is associated with dysfunction of the enteric神经系统和肠运动。据报道，叶黄素是一种天然存在的黄酮，具有潜在的药理学活性在肠道炎症和神经损伤方面。蒂S研究旨在探讨叶黄素及其功能机制在洛哌酰胺诱导的FC小鼠中的作用。我们的结果表明，Luteolin治疗逆转了排便频率，粪便水含量和肠道转运比的降低，以及FC模型的运输时间的升高。一致地，叶黄素增加了肌肉层的厚度，并减少了洛哌丁胺诱导的结肠组织病理学损伤。 Furthermore, we revealed that luteolin treatment increased the expression of neuronal protein HuC/D and the levels of intestinal motility-related biomarkers, including substance P (SP), vasoactive intestinal polypeptide (VIP), and acetylcholine (ACh), as well as interstitial cells of Cajal (ICC) biomarker KIT proto-oncogene, receptor tyrosine激酶（C-KIT）和Anoctamin-1（ANO1），这意味着叶黄素介导的结肠功能增强，并导致针对洛泊酰胺诱导的FC的抗智能运动障碍。另外，黄体素减少了在FC小鼠的结肠中，Aquaporin（AQP）-3，AQP-4和AQP-8的上调。总而言之，我们的数据表明，叶黄素素可能是开发FC搭载药物的有吸引力的选择。