心血管疾病患者中补充维生素D对血糖控制，脂质谱和C反应蛋白的影响：对随机对照试验的系统评价和荟萃分析。
摘要来源：摘要来源：
curr pharm pharm des。 2019年3月8日。EPUB2019 3月8日。PMID： 30854952“> 30854952” Alireza Milajerdi，Majid Ghayour-Mobarhan，Gordon Ferns，Mohsen Taghizadeh，Bita Badehnoosh，Hamed Mirzaei，Zatollah Asemi Asemi
文章隶属关系：vahidreza ostadmohammahammAmhammahammaMahammAmhammadi 胰岛素抵抗，血脂异常和慢性炎症是心血管疾病（CVD）的重要危险因素。因此，补充维生素D可能是减少CVD并发症的适当方法。这项系统的审查和荟萃分析旨在确定ine the effects of vitamin D supplementation on glycemic control, lipid profiles, and C-reactive protein among patients with coronary artery disease.
METHODS: Two independent authors systematically searched online database including EMBASE, Scopus, PubMed, Cochrane Library, and Web of Science were searched until 2018年9月20日。采用偏置工具的Cochrane协作风险来评估纳入试验的方法论质量。使用Cochrans Q检验和I-Square（I2）统计量评估了纳入研究之间的异质性。 Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size.
RESULTS: A total of eight trials (305 participants in the intervention group and 325 in placebo group) were included in the current meta-analysis.研究的合并效应大小显示出显着的空腹葡萄糖（WMD）的减少：-15.67; 95% CI: -29.32, -2.03), insulin concentrations (WMD: -3.53; 95% CI: -4.59, -2.46) and homeostatic model assessment of insulin resistance (WMD: -1.07; 95% CI: -1.49, -0.66), and significant increase in the quantitative insulin-sensitivity check index (WMD: 0.02; 95％CI：0.01，0.03）进行维生素D。此外，汇总分析显示，维生素D治疗后血清HDL-胆固醇浓度显着增加（WMD：3.08; 95％CI：1.42，4.73）。 Additionally, vitamin D supplementation significantly reduced C-reactive protein (CRP) levels (WMD: -0.75; 95% CI: -1.28, -0.23).
CONCLUSIONS: This meta-analysis demonstrated the beneficial effects of vitamin D supplementation on improving CVD患者中的血糖控制，HDL-胆固醇和CRP水平，尽管它不影响甘油三酸酯，总和LDL-胆固醇水平。