Eur Rev Med Pharmacol Sci。 2015年4月； 19（7）：1305-14。 PMID： 25912594 jin
文章隶属关系：t ma
摘要：
客观： ，观察姜黄素对姜黄素表达水平对核因子κB-p65（NF-κB-p65）的表达水平（nf-κB-p65）和tumor necror necrul nimul act inf-nf-α（tnf-α）椎间盘变性。并研究姜黄素在减速腰椎椎间盘变性过程中的作用的机制。
材料和方法： 在sprague-dawley（SD）大鼠中建立了腰椎椎间盘变性的模型，然后进行姜黄素治疗。评估了SD大鼠腰椎椎间盘的超微型结构组织形态变化。 The protein and gene expression levels of NF-κB-p65 and TNF-α in the lumbar intervertebral disc were measured.
RESULTS: Magnetic resonance imaging (MRI) and histomorphology confirmed the establishment of a successful lumbar intervertebral disc degeneration model. MRI和超微型结构的结果表明，姜黄素治疗组（低剂量和高剂量）在腰椎椎间盘变性方面有显着改善。仅在用二甲基磺胺（DMSO）处理的溶剂对照组中未观察到显着变化。基于Western印迹分析和R的结果与未经姜黄素治疗的组相比，EAL时间PCR，姜黄素治疗（低剂量和高剂量）可显着降低腰椎椎间盘组织NF-κB-P65和TNF-α的表达水平。 No significant difference, however, was observed between the low-dose and high-dose curcumin treatment groups.
CONCLUSIONS: Curcumin may inhibit the activation of NF-κB by inhibiting the translocation of NF-κB-p65 and reducing the release of inflammatory factors which, thereby, decelerates the process腰椎椎间盘变性。