Click here to read the complete article.
Abstract Title:Research progress on antidepressant effects and mechanisms of berberine.
Abstract Source:
前药物。 2024; 15：1331440。 EPUB 2024 JAN22。PMID： 38318145 Wang，Hui Dong，Yueheng Tang
文章隶属关系：Yang Gao
摘要：抑郁症，这是一个日益普遍的全球健康问题，对患者的日常生活产生了严重影响。但是，目前在临床中使用的抗抑郁药不是完全有效的，这大大降低了患者的依从性。 berberine是一种天然的四元生物碱，已被证明具有多种药理作用，例如降血糖，脂质调节，抗癌，抗菌，ANT-氧化，抗炎和抗抑郁药。 This review summarizes the evidence of pharmacological applications of berberine in treating depression and elucidates the mechanisms of berberine regulating neurotransmitter levels, promoting the regeneration of hippocampal neurons, improving hypothalamic-pituitary-adrenal axis dysfunction, anti-oxidative stress, and suppressing inflammatory status in order to provide a reference for further research and clinical application of berberine。