perilla frutescens精油通过单胺神经递质和BDNF/TRKB信号途径的抗抑郁作用。
摘要来源：
j ethnopharmacol。 2024年1月10日； 318（PT A）：116840。 Epub 2023 Jun23。pmid： 37355083“> 37355083 Zheng, Ming Yang, Pengyi Hu, Qiyue Yang, Huanhua Xu, Zhenfeng Wu, Xiaoying Huang, Huiting Li, Mingxia Tang, Huiming Zeng, Liyun Zhu, Guilin Ren, Ming Cao, Yu Liu, Hongbo Wang
Article Affiliation:Yu Zhong
Abstract:
民族药理学相关性： 传统中药认为影响疾病的不良症状是抑郁症的主要原因，Qi运动停滞作为其发病率。因此，抑郁症的临床治疗应确定调节气和缓解抑郁症状的优先级。药理道具中药的埃特氏症表明，佩里拉·弗雷特赛（Perilla Frutescens）可能会对抑郁症和其他神经精神疾病产生潜在的治疗作用，因为它可以调节气体和减轻抑郁症状。 Although previous studies have reported the antidepressant effects of Perilla frutescens, the mechanism underlying PFEO inhalation-mediated antidepressant effect remains unclear.
AIM OF THE STUDY: The aim of this investigation is to elucidate the antidepressant mechanisms of PFEO by examining its effects on单胺神经递质和BDNF/TRKB信号通路。
材料和方法： 抑郁症的暨被建立，并通过货币的抑郁状态通过货物的抑郁状态进行评估。进行ELISA分析以确定海马和CERE中的单胺神经递质水平大鼠的乳状皮质。 Immunohistochemistry, western blotting, and RT-PCR experiments were employed to investigate the BDNF/TrkB signaling pathways regulation of depression via PFEO inhalation.
RESULTS: It has been observed that inhalation administration of PFEO can significantly enhance the preference for sugar water in CUMS在强迫游泳期间，大鼠并减少其固定时间。此外，这些大鼠的海马和脑皮质中的单胺发射器水平都在增加。 Furthermore, there was an upregulation in the expression levels of BDNF and TrkB positive cells as well as BDNF and TrkB proteins within both regions, along with increased BDNF mRNA and TrkB mRNA expression levels.
CONCLUSION: The antidepressant effect of PFEO via inhalation administration is推测要通过单胺神经递质介导和bdnf/trkb信号通路。