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Abstract Title:Antidepressant effects of aqueous extract of saffron and its effects on CREB, P-CREB,大鼠小脑中的BDNF和VGF蛋白。
摘要来源：
j Pharmacacuncture。 2018年3月； 21（1）：35-40。 EPUB 2018 3月31日。PMID： 30151303“> 30151303 Khalil Abnous，Bibi Marjan Razavi，Mrazieh Rashednia，Faezeh Vahdati Hasani，Hossein Hosseinzadeh
文章隶属关系：najmeh asrari
摘要摘要：摘要：
Methods: Saffron aqueous extract (40 and 80 mg/kg/day) and imipramine (10 mg/kg/day) were administered对大鼠的腹膜内21天。在实验结束时，牺牲动物并分离小脑。 The protein levels of BDNF, VGF, CREB and P- CREB in the rat cerebellum were evaluated using western blot analysis.
Results: Saffron aqueous extract (80mg/kg/day) caused significant increase in protein level of P-CREB in long term treatment in the rat cerebellum. VGF，CREB和BDNF的蛋白质水平的升高并不显着。
结论： 总而言之，我们的结果表明，我们的结果表明，saffron e e e e e e e e e贝贝鲁姆的抗抑郁效应可能引起Creb的磷酸化。