抽象来源： neurosci lett。 2022年11月20日; 791：136912。 EPUB 2022 10月13日。PMID： 36244518 36244518
class =“ sub_abstract_label”>简介： 藏红花，鳄鱼Sativus L.的干污于伊朗专门用于烹饪Persos的著名且高价值的农业产品E且众所周知，可以用抗氧化剂和抗炎活性来治疗情绪和认知障碍。但是，藏红花的大多数药用特性与其主要成分crocin相关。几项基于证据的研究证实了应力激素与抑郁症之间的强正相关。 The main aim of the present study is to determine the potential antidepressant effects of crocin, saffrons constitute, in unpredictable chronic mild stress (UCMS) induced anxiety and depression in rats.
MATERIALS AND METHODS: The rats were treated as 1) Vehicle with saline, 2) UCMS, 3-5) UCMS-鳄鱼蛋白10、20和30 mg/kg通过口服烤架，6）用口服烤烤30 mg/kg的车辆。雄性Wistar大鼠总共进行4周的UCM。在4周内，他们接受了七项培训试验。行为测试后，收集大鼠脑切片以检查炎症和氧化应激Damage criteria.
RESULTS: Serum corticosterone levels, cortical malondialdehyde (MDA), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were increased in rats exposed to UCMS, while UCMS decreased IL-10 superoxide dismutase (SOD), Catalase (CAT, and thiol. In addition, UCMS decreased brain-derived neurotrophic factor (BDNF) level in cortical tissues. Crocin improved the behaviors of the UCMS rats in the open field (OF, elevated plus maze (EPM), and forced swimming (FS) tests and reversed the effects of UCMS in all measured参数。
结论： 鳄鱼通过降低脑氧化应激，炎症介质，炎症性介质和皮质糖酮血清水平来减轻UCMS诱导的焦虑和抑郁。