生物化药物。 2021年10月12日; 144：112291。 EPUB 2021 10月12日。PMID： 34653760 Satoshi Fukumitsu, Hidetoshi Kuwata, Hiroko Isoda
Article Affiliation:Kazunori Sasaki
Abstract:BACKGROUND: Oxytocin (OXT), a neuropeptide involved in mammal reproductive and prosocial behaviors, has据报道会与各种具有压力源的神经生物学变化相互作用，包括神经内分泌，神经递质和炎症过程。我n view of disturbances in psychosocial relationships due to social isolation and physical distancing measures amid the COVID-19 pandemic, being one of the triggering factors for the recent rise in depression and anxiety, OXT is a potential candidate for a new antidepressant.
METHODS: In this present study, we have aimed to investigate the effects of在小鼠模型中其他应力生物标志物和神经递质水平的背景下，从迷迭香精油的蒸馏残留物中提取的Rosmarinus officinalis提取物（RE）的口服给药。 LPS注射后的尾悬浮测试（TST）和升高的迷宫测试（EPMT）分别用于评估小鼠的抑郁和焦虑症行为。
发现：发现： for Re for Re for 7天的预防效果，可以在七天进行7天的改善。全基因组微阵列分析r探测显着逆转了与催产毒素能和神经递质途径和炎症过程有关的基因表达中TST胁迫诱导的改变。在这两个模型中，重新均显着提高了中央OXT和OXTR表达以及OXT蛋白水平。 RE also significantly attenuated stress-induced changes in serum corticosterone, brain and serum BDNF levels, and brain neurotransmitters levels in both models.
INTERPRETATION: Altogether, our study is the first to report antidepressant- and anxiolytic-like activities of RE through modulating小鼠大脑中的催产系统，因此强调了对心理心理抑郁症的治疗的前景。