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摘要来源：
前精神病学。 2023; 14：1302559。 EPUB 2024 1月8日。PMID： 38264636“> 38264636 Dornbierer, Dila Suay, Claudius Elsner, Ilhui Wicki, Daniel Meling, Luzia Caflisch, Alexandra Hempe, Camilla Steinhart, Jovin Mueller, Robin Von Rotz, Birgit Kleim, Milan Scheidegger
Article Affiliation:Helena D Aicher
Abstract:背景： 越来越多的科学证据证明了亚马逊植物性植物性的迷幻“ ayahuasca”对神经精神病的益处抑郁症和焦虑等疾病。但是，将植物性ayahuasca纳入生物医学研究和临床治疗环境时，存在一些挑战。 Formulations inspired by ayahuasca, which contain specific and standardized active components, are a potential remedy.
METHODS: We investigated subjective acute and persisting effects of a novel formulation containing the reversible monoamine oxidase inhibitor harmine (orodispersible tablet containing 100 mg MAO-I) and N,N-dimethyltryptamine (incremental intranasal dosing of up to 100 mg DMT), compared with two other conditions, namely harmine alone and placebo, in a crossover RCT in 31 healthy male subjects.
RESULTS: DMT + harmine, but not harmine alone, induced通过5D-ASC评级量表进行评估的迷幻经验[全局得分：（2,60）= 80.21，<0.001]和急性体验抽样随着时间的推移，物品的特征是心理学见解[PIQ，（2,58.5）= 28.514，<0.001]，情感突破[EBI，（2,60）= 26.509，<0.001]，在具有挑战性的体验问卷[CEQ，（2,60）= 12.84，<0.004，<0.004，<0.004，<0.001]上得分较低。参与者将个人和精神意义归因于经验（GSR），主要是1个月和4个月的随访，主要是积极的持久效应（PEQ）。急性药物作用与持续作用正相关。 We found no changes in trait measures of personality, psychological flexibility, or general well-being, and no increases in psychopathology (SCL-90-R) were reported.
DISCUSSION AND CONCLUSION: Our results suggest that the experience induced by the standardized DMT + harmine formulation induces a phenomenologically rich psychedelic经验，表现出良好的心理安全性和耐受性，具有良好的耐受性，并引起有益的心理过程D可能支持心理治疗。需要进一步的研究来研究患者的心理治疗潜力。