情绪相关的网络在抑郁的双极后代补充鱼油后的重组:基于fMRI的基于图形的连接组分析。
摘要来源:
j j影响疾病。 2021 09 1; 292:319-327。 EPUB 2021 6月5日PMID: 34139404 34139404 Rodrigo Patino,Qiyong Gong,Jeffrey R Strawn,Melissa P Delbello,Robert K McNamara
文章隶属关系:Wenbin li
摘要:
方法:方法: 在基线患者中与健康对照(n = 53)进行了比较(n = 53),以及n = 53),以及n = 53),n = 53),n = 53)安慰剂或鱼油。在基线和端点时,测量了红细胞EPA+DHA水平,并在执行情绪和中性的分散障碍(CPT-END)执行连续的性能任务时获得了fMRI扫描(4 tesla)。 Graph-based analysis was used to characterize topological properties of large-scale brain network organization.
RESULTS: Compared with healthy controls, patients exhibited lower erythrocyte EPA+DHA levels (p = 0.0001), lower network clustering coefficients (p = 0.029), global efficiency (p = 0.042), and较低节点中心和连接额叶区域中的抗距强度(p <0.05)。与安慰剂相比,补充12周的鱼油EPA+DHA水平(p <0.001),网络聚类系数(P = 0.005),全球(P = 0.047)和局部(P = 0.023)效率(P = 0.023),以及节点核心,主要是临时区域(P <0.05)。 class="sub_abstract_label">LIMITATIONS: The duration of fish oil supplementation was relatively short and the sample size was relatively small.
CONCLUSIONS: These findings provide preliminary evidence that abnormalities in emotion-related network organization observed in depressed high-risk youth may be可以通过补充鱼油进行修饰。