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Abstract Title:The Therapeutic Effect of Exogenous Melatonin on Depressive Symptoms: A Systematic Review and荟萃分析。
摘要来源：
正面精神病学。 2022; 13：737972。 EPUB 2022 3月17日。PMID： 35370838“> 35370838 Xuan Zhao，Yuanyuan Heng，Delong MA，Enoch Odame Anto，Yanbo Zhang，Mingyun niu，Wangxin Zhang Zhang
文章隶属关系：cancan li
摘要：
Methods: We searched the online databases of PubMed, EMBASE, and the Cochrane Library for original studies published up to May 2021. We used STATA 14.0 software to synthesize the results of included研究。 To evaluate the effectiveness of melatonin, we calculated the standardized mean differences (SMDs) and 95% confidence intervals (CIs) of depression scores between the melatonin and placebo groups.
Results: Our literature search returned 754 publications, among which 19 studies with 1,178 patients (715 women, 463男性；平均年龄：56.77年）符合包容性标准。褪黑激素剂量为每天2至25毫克；治疗时间在10天到3。5年之间。我们合成的结果表明，未发现褪黑激素显着有益于缓解抑郁症状（SMD = -0.17，95％CI = [-0.38，0.05]）。亚组分析表明，用BECK抑郁量库存测得的抑郁得分的降低显着（SMD = -0.52，95％CI = [-0.73，-0.31]）。
结论：抑郁。