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抽象来源:
糖尿病护理。 2004年2月; 27(2):348-53。 PMID: 14747212“> 14747212 Brant
文章隶属关系:Steven M Willi
摘要:
目标: 当前批准用于2型糖尿病(元成蛋白和胰岛素)儿童中的药理药物,对于某些患者而言少于最佳。我们评估了在2型糖尿病的治疗中使用生酮,非常低的卡路里饮食(VLCD)。
研究设计和方法S: 我们对20名儿童(平均年龄14.5岁+/- 0.4岁)进行了图表审查,他们在治疗2型糖尿病时食用了生酮VLCD。 Several response variables (BMI, blood pressure, HbA(1c), blood glucose, and treatment regimens) were examined before, during, and up to 2 years after the diet and compared with a matched diabetic control group.
RESULTS: Before starting the diet, 11 of 20 patients were treated with insulin and 6 with metformin.在VLCD的前3天中,平均每日血糖值从8.9 +/- 1.1降至5.5 +/- 0.38 mmol/L(p <0.0001),使胰岛素和口服剂在除一个受试者外都可以停止。 BMI从43.5 +/- 1.8降至39.3 +/- 1.8 kg/m(2)(p <0.0001)和HBA(1C)从8.8 +/- 0.6 +/- 0.6 +/- 0.4 +/- 0.6%(P <0.005)下降,因为饮食持续了60 +/- 8天(4-130天)(4-130天)(范围为4-130天),而无需依赖的依赖于侵略的侵略。持续减少s in BMI and insulin requirements were observed in patients remaining on the VLCD for at least 6 weeks when compared with those of the control group.
CONCLUSIONS: The ketogenic VLCD is an effective short-term, and possibly long-term, therapy for pediatric patients with type 2 diabetes.血糖控制和BMI改善,使外源胰岛素和其他抗糖尿病药的停用。这种饮食虽然严格,但有潜力作为糖尿病个体的这一新兴子集的药理疗法的替代方法。