饮食抗氧化能力和2型糖尿病的风险。 2017年11月9日。epub 2017 11月9日。pmid： 29119242“> 29119242”> 29119242 Affret, Courtney Dow, Beverley Balkau, Fabrice Bonnet, Marie-Christine Boutron-Ruault, Guy Fagherazzi
Article Affiliation:Francesca Romana Mancini
Abstract:AIMS/HYPOTHESIS: Recent evidence suggests that oxidative stress may有助于2型糖尿病的发病机理。饮食，尤其是水果和蔬菜，含有各种具有抗氧化活性的化合物，可能具有累积/协同的抗氧化作用。总抗氧化能力是从饮食摄入中得出的指数，是所有饮食中的抗氧化能力的单一估计值贵族。 The main aim of this study was to investigate the relationship between total antioxidant capacity and risk of type 2 diabetes.
METHODS: Among 64,223 women (mean age 52 ± 7 years) from the French E3N-European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, 1751 women had在随访15年期间经过验证的2型糖尿病。用还原离子抗氧化能力（FRAP）方法估算了总抗氧化能力。 AdjustedCox proportional hazards regression models were used to calculate HRs and 95% CIs for the associations between total antioxidant capacity and type 2 diabetes risk, adjusted for potential confounders.
RESULTS: In multivariable models, higher levels of total antioxidant capacity were associated with a lower risk of type 2 糖尿病。与最低五分位数的女性相比，第三，第四和第五的女性总抗氧化能力的五分位数分别为0.74（95％CI 0.63，0.86），0.70（95％CI 0.59，0.83）和0.73（95％CI 0.60，0.89）。 The inverse association between total antioxidant capacity and risk of type 2 diabetes was linear up to values of 15 mmol/day, after which the effect reached a plateau.
CONCLUSIONS/INTERPRETATION: Our findings suggest that the total antioxidant capacity may play an important role in reducing the risk of type 2 diabetes in中年妇女。有必要进行更多的研究，以更好地了解这种反相关性的生物学机制。