通过AMPK上调和抗氧化活性，甜叶菊redaudiana提取物的1型糖尿病大鼠骨骼肌肉中代谢功能障碍的衰减。
摘要来源：摘要：
acta sci pol Technol Technol Aliment。 2018年7月; 17（3）：289-297。 PMID： 30269468”> 30269468 Elazab, Sahar A M Hussein, Abdelaziz M Hussein
Article Affiliation:Amani M D El-Mesallamy
Abstract:BACKGROUND: Stevia rebaudiana Bertoni leaves are well-known for their sweetness and have been used as a non-caloric sweetener in several countries.它具有众多的治疗特性，这些特性已被证明是安全有效的数百年。在本研究中，我们旨在评估甜叶菊提取物的可能抗氧化作用及其在调节中的作用1型糖尿病大鼠中的AMPK。
方法： 五十只雄性sprague dawely大鼠分为：（1）正常对照（1）正常对照（NC）组；正常大鼠接受0.5 mL正常盐水，（2）DM组；糖尿病大鼠接受0.5 mL正常盐水，（3）DM + MSE组； DM大鼠接受200 mg/kg甜叶菊的甲醇提取物，（4）DM + S组； DM大鼠接受2 mg/kg的纯叶叶固定剂，（5）DM + CGA组； DM大鼠接受10 mg/kg的纯绿化酸。治疗后四个星期，在冷冻肌肉中测量了AMPK活性，GLUT4 mRNA和氧化应激标记。 Also, fasting blood glucose in serum, insulin and HbA1c were measured at the end of experiment.
RESULTS: DM caused a significant increase in serum fasting glucose, HbA1c and muscle MDA with significant reduction in serum insulin, muscle SOD, catalase, GPx, AMPK活性和GLUT4表达（P <0.05）。智慧h stevia extract, pure stevioside and chlorogenic acid caused significant improvements in the studied parameters (p<0.05).
CONCLUSIONS: We concluded that stevia extracts and derivatives may improve metabolic dysfunction in skel- etal muscles via upregulation of AMPK and Glut4和抑制氧化应激。