Notoginsenoside R1可以抑制FGF1和VEGFA之间的相互作用，从而延迟足细胞凋亡

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Notoginsenoside R1 can inhibit the interaction between FGF1 and VEGFA to retard足细胞凋亡。

bmc内克疾病。 2023年7月6日； 23（1）：140。 EPUB 2023 7月6日。PMID： 37415174 37415174 JingYuan Ma, Zhang Liang, Le Zhang, Tao Liu, WenXing Fan

ChangYan Li

BACKGROUND: Diabetic nephropathy (DN) is a chronic condition resulting from microangiopathy in a high-glucose 环境。 DN中血管损伤的评估主要集中在VEGF的活性分子上，即VEGFA和VEGF2（F2R）。 Notoginsenoside R1（NGR1），一种传统的抗炎药位血管活性。因此，识别具有血管炎症性保护的经典药物以治疗DN是一种有价值的追求。

方法： “ limma”方法用于分析肾小球转录组的靶标，同时分析swiSs aLgorman swiss swirs swirs swirs swirs swirs swirs swirs swirs swirs swirs swirs swirss swirs swilgorsh swiiss swirss swirs swilgorsh swilgorsh NGR1。 The molecular docking technique was employed to investigate the relationship between vascular active drug targets, and the COIP experiment was conducted to verify the interaction between fibroblast growth factor 1 (FGF1) and VEGFA in relation to NGR1 and drug targets.

RESULTS: According to the Swiss target prediction, the LEU32（B）血管内皮生长因子A（VEGFA）蛋白以及Lys112（a），Ser116（a）和His102（b）位点的成纤维细胞生长因子1（FGF1）蛋白的lys112（a），Ser116（a）和His102（b）位点是潜在的NG的潜在结合位点的位点R1通过氢键。此外，共免疫沉淀（COIP）结果表明VEGFA和FGF1蛋白可以彼此相互作用，而NGR1可以阻碍这种相互作用。 Furthermore, NGR1 can suppress the expression of VEGFA and FGF1 in a high-glucose environment, thereby decelerating podocyte apoptosis.

CONCLUSION: The inhibition of the interaction between FGF1 and VEGFA by NGR1 has been observed to decelerate足细胞凋亡。