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Abstract Title:Protective mechanisms of Cucumis sativus in diabetes-related modelsof oxidative stress and羰基应力。
抽象来源：
生物影响。 2016; 6（1）：33-9。 EPUB 2016 3月28日。PMID： 27340622 27340622
Noubarani, Mokhtar Rahmati, Iman Jafarian, Hasan Adiban, Mohammad Reza EskandariArticle Affiliation:Himan Heidari
Abstract:INTRODUCTION: Oxidative stress and carbonyl stress have essential mediatory roles in the development of糖尿病及其相关并发症通过增加自由基的产生和损害抗氧化剂防御系统。不同的化学和天然化合物已经因减少与糖尿病相关的这种疾病而被uggest。本研究的目的是研究氧化和羰基应激模型中黄瓜（C. sativus）果实（C. sativus）果实（Cucumber）的保护作用。 These diabetes-related models with overproduction of reactive oxygen species (ROS) and reactive carbonyl species (RCS) simulate conditions observed in chronic hyperglycemia.
METHODS: Cytotoxicity induced by cumene hydroperoxide (oxidative stress model) or glyoxal (carbonyl stress model) were measured and the protective effects of C. sativus were evaluated using freshly isolated rat hepatocytes.
RESULTS: Aqueous extract of C. sativus fruit (40μg/mL) prevented all cytotoxicity markers in both the oxidative and carbonyl stress models including cell裂解，ROS形成，膜脂质过氧化，谷胱甘肽的耗竭，线粒体膜ANE的潜在下降，溶酶体唇和蛋白水解。该提取物还保护肝细胞免受乙二醛诱导的蛋白羰基的影响。我们的结果表明，C. sativus能够预防孤立的肝细胞中的氧化应激和羰基应激。
结论： 可以结论一下，可以将固定杆菌的固定效果视为对糖尿病的影响，并且可以被认为是糖尿病的效果。通常在糖尿病中观察到的压力。