[ursolic酸对糖尿病及其机制小鼠心肌病的影响]。
摘要来源：
e
Zhongguo ying ying yong yong yong yong yong yong yong li xue Za Zhi Zhi。 2018年4月8日; 34（4）：309-312 339。pmid： 3078888937
Yang, Hui-Lin Xu, Yin Cheng, Jin-Guo Zhao, Yu-Jie Zhou, Yang-Jing Weng, Xu-Tao Wang, Min-You QiArticle Affiliation:Zhang-Liang Yang
Abstract:OBJECTIVE: To study the effect of ursolic acid on cardiomyopathy in mice with diabetes induced by high-fat diet combined with low dose streptozotocin, and to explore its possible mechanism.
METHODS: Thirty male ICR mice were randomly divided into control group (=10) and moulding group (=20), the mice in两组分别以常规饮食和高脂饮食喂食6我们EKS，然后将成型组中的小鼠连续5天注射链蛋白酶（30 mg/kg），以诱导糖尿病（DM）。 9天后测量空腹血糖（FBG）。 FBG超过11.1 mmol/L的小鼠被视为DM。将二十只DM小鼠随机分为模型组和ursolic酸组（= 10）。每组中的小鼠连续地施用Ursolic Acid（100 mg/kg）或相应的溶剂内术中持续8周。之后，测量FBG，体重（BW），心脏重量和左心室重量，以计算心脏质量指数（HMI）和左心室质量指数（LVMI）。检测到心肌组织中肌酸激酶（CK），乳酸脱氢酶（LDH）的水平，超氧化物歧化酶（SOD），丙二醛（MDA）的水平。他的染色用于观察心肌组织的病理变化。采用免疫组织化学来确定点样受体蛋白3的表达（NLRP3) and interleukin 1β (IL-1β).
RESULTS: Compared with the control group, HMI, LVMI were apparently enlarged, levels of FBG, CK, LDH in serum and MDA in myocardial tissue were extremely increased, while the activity of SOD in myocardial糖尿病组的组织降低了。他对心肌染色表明，心肌细胞中的心肌纤维，水肿和肥大的布置障碍以及模型组的炎性细胞浸润。 Immunohistochemistry showed that the expression of NLRP3 and IL-1β in myocardial tissue increased obviously in model group, the above changes inursolic acid group were significantly ameliorated.
CONCLUSIONS: Ursolic acid has a obvious protective effect on myocardial injury in mice with diabetes induced by高脂肪饮食与低剂量链霉菌素结合，其机制可能与抑制作用有关ITing NLRP3炎性体激活，减少IL-1β的产生并减轻心肌炎症损伤。