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Abstract Title:Low-level laser therapy with 810 nm wavelength improves skin wound healing in rats with链霉菌素诱导的糖尿病。
摘要来源：
photomed激光外科手术。 2014年4月； 32（4）：198-204。 EPUB 2014 3月24日。PMID： 246661084 24661084 Ivan Kováč, Katarína Jakubčová, Martin Hollý, Viera Revajová, František Sabol, Zoltán Tomori, Marjolein Iversen, Peter Gál, Jan M Bjordal
Article Affiliation:Ludmila Dancáková
Abstract:目标： 本研究的目的是评估低级激光疗法（LLLT）是否可以逆转糖尿病大鼠中伤口愈合的伤口愈合过程。
糖尿病患者伤口愈合受损是一个主要的健康问题。 Recent studies have indicated that LLLT may improve wound healing in diabetic rats, but the optimal treatment parameters are still unknown.
MATERIALS AND METHODS: Male Sprague-Dawley rats (n=21) were randomly divided into three groups: a healthy control group, a diabetic sham-treated group, and a diabetic LLLT处理的组。然后，通过链蛋白酶给予两个糖尿病基团诱导糖尿病。在每只大鼠的背面进行了一个4厘米长的全厚皮肤切口和一个完整的厚度圆形切除（直径= 4 mm）。 An infrared 810 nm laser with an output of 30 mW, a power density of 30 mW/cm(2), and a spot size of 1 cm(2) was used to irradiate each wound for 30 sec (daily dose of 0.9 J/cm(2)/wound/day).
RESULTS: In diabetIC大鼠是经过LLLT治疗的切除术的组织学表明，与非糖尿病对照组的愈合反应相似，其成熟肉芽组织比在假治疗的糖尿病对照组中要成熟得多。 LLLT reduced the loss of tensile strength, and increased the incision wound stiffness significantly compared with sham-irradiated rats, but this did not achieve the same level as in the nondiabetic controls.
CONCLUSIONS: Our study demonstrates that infrared LLLT can improve wound healing in diabetic rats.然而，需要进一步研究以评估确切的潜在机制并进一步优化临床使用的LLLT参数。