激光疗法将糖尿病伤口愈合转化为正常愈合

OBJECTIVE: We have determined optimal laser dosimetric parameters in comparison with polychromatic light-emitting diodes (LEDs) that can speed up healing in four animal models: non-diabetic oval full-thickness wounds, diabetic oval full-thickness wounds, Sprague-Dawley大鼠中的非糖尿病性燃烧和糖尿病烧伤。

材料和方法： 这一系列研究使用了532-，633-，633-，810-，810-，980-，980-，和10,600-ch for for for for for for for for for for dociftor dolory dolory dolorantor dolorranical dolorrolosic （510-872 nm，可见红外线）作为光子来源。使用了Sprague-Dawley大鼠（n = 893）； however, animals that died before and during the experiments from anesthesia accidents and for any other reason were excluded from statistical analysis.

RESULTS: The improvements seen (>10% improvement of impairment) show that phototherapy with the 633-nm laser is quite promising for alleviating diabetic wound and burn healing,并分别提高了38.5％和53.4％的改善。

结论： 在这种诱导的糖尿病型，伤口模型，伤口和烧伤愈合中，均提高了40.3％和45％，在63333333-NM LESERINE中均得到了40.3％和45％的伤害。通过光疗加速。这表明在光疗治疗的糖尿病大鼠中将治愈率归一化。鉴于这些有趣的发现，在4.71 j/cm（2）PE时进行633 nm激光治疗3次R剂量用于糖尿病性灼伤，建议每剂量为2.35 J/cm（2），用于糖尿病伤口愈合作为人类临床试验的实际剂量，尤其是在治愈受损的患者（例如糖尿病患者和老年人）进行大手术后。