椭圆酸可以预防大鼠与糖尿病相关的行为缺陷：可能涉及的机制。
摘要来源：
life sci。 2019年3月31日。EPUB2019 3月31日。PMID： 30943382 Shahab Ghaderi，Seyed Esmaeil Khoshnam，Alireza Sarkaki，Khodabakhsh Rashidi，Mohammad Rashno，Mohammad Badavi
文章隶属关系：yaghoob farboob farbood farbood farbood farbood
摘要：p>
主要方法： 五十只成年男性Wistar大鼠被随机分为五组：即用车辆治疗的con：正常大鼠，用车辆治疗（5ml/kg/kg/kg/kg/kg/kg/kg/kg/kg/kg/kg/kg/kg/kg;用媒介物（5ml/kg/day; P.O.），STZ+INS：用胰岛素治疗的糖尿病大鼠（6IU/RAT/DAY； S.C.），STZ+EA：用EA（50mg/kg/Day; P.O.）处理的大鼠。所有组连续八周接受治疗。在第七周和第八周，通过常用的行为测试评估大鼠的行为功能。 Subsequently, pro- and anti-inflammatory cytokines, neurotrophic factors, and also histological changes were evaluated in both cerebral cortex and hippocampus of the rats.
KEY FINDINGS: Chronic EA treatment attenuated anxiety/depression-like behaviors, improved exploratory/locomotor活动，糖尿病大鼠的认知缺陷得到改善。这些结果伴随着血糖水平降低，炎症状态的调节，改善神经营养的支持以及糖尿病大鼠神经元丧失的改善。 In some aspects, treatment with EA was even more effective than insulin therapy.
SIGNIFICANCE: The current works data confirms that EA could potentially serve as a novel, promising, and accessible protective agent against diabetes-associated behavioral deficits, owing to its anti-hyperglycemic, anti-inflammatory, and神经营养特性。