通过抑制葡萄糖转运蛋白和肾素 - 血管紧张素系统。
抽象来源:
营养。 2019年7月1日; 67-68:110543。 EPUB 2019年7月1日PMID: 31408826 31408826 Krishnapura Srinivasan
Article Affiliation:Seetur R Pradeep
Abstract:OBJECTIVES: The aim of this study was to determine the effects of dietary fenugreek (Trigonella foenum-graecum) seeds and onion on the hyperglycemia-stimulated葡萄糖转运蛋白和肾素 - 血管紧张素系统介导的事件的级联激活导致糖尿病动物的肾脏病变。
方法: 在链蛋白酶糖尿病糖尿病大鼠中研究了饮食中的胡芦巴种子(10%)和洋葱(3%)的流畅性。 Renal damage was assessed by measuring proteinuria, enzymuria, expression of glucose transporters, renin-angiotensin system, and activities of polyol pathway enzymes.
RESULTS: Diabetes resulted in an upregulation of glucose transporters in kidney tissue, which was countered by these dietary干预措施。这些饮食干预措施也应对肾血管紧张素转换酶及其受体的上调。饮食中的胡芦巴和洋葱可显着降低多元醇途径,一氧化氮和N-乙酰基-β-β-D-葡萄糖胺酶活性的代谢产物。通过这些饮食干预措施将肾脏损伤分子1表达的肾脏排泄标记肾脏(肾蛋白,足球素和足病蛋白)及其尿液排泄的标志。膳食胡芦巴and onion effectively countered the diabetes-induced structural abnormalities of renal tissue.
CONCLUSION: Feeding fiber-rich fenugreek seeds and sulfur compounds-rich onion produced a blockade in glucose translocation and renin-angiotensin system in the early stage of diabetic肾病。这涉及多元途径酶的表达,部分恢复足细胞损伤,肾脏结构的复兴和功能异常。本研究还表明,这两种饮食干预措施一起消费时会产生更高的肉变保护影响。