6-shogaol可以用作预防糖尿病患者并发症的治疗剂

Jun-Koo Yi

Background: Diabetes is characterized by hyperglycemia due to impaired insulin secretion and aberrant glucagon secretion resulting from changes in胰岛细胞功能和/或质量。本研究的目的是研究生姜对各种组织的影响（即PAN链蛋白酶诱导的糖尿病小鼠中的CREA，肾脏和肝脏）和胰岛素抵抗。 The pleasant aroma of ginger comes from the constituents present in its volatile oil, while its non-volatile pungent phytochemicals consist of gingerols, shogaols, and paradols.

Methods: This research was conducted to determine the effects of 6-shogaol administration on blood glucose and 1型糖尿病小鼠的胰岛素产生。小鼠在5或10 mg/kg体重的腹膜内注射Shogaol。未处理的小鼠注射了同等量的缓冲液，每周3次，持续2周。 The animals were randomly divided into four experimental groups: control group mice (n = 3) were given an intraperitoneal (IP) injection of streptozotocin (STZ) vehicle (1 mLcitrate buffer/100 g body weight) at day 1 and received an IP injection of 6-shogaol vehicle [1 mL buffer (0.5% DMSO, 10% Tween 20, and 89.5% PBS)/100 g body weight]

结果：

结果： 6-shogaol表现出抗糖尿病的作用，通过显着降低血糖，体重的水平，使上述病理变化对糖尿病的正常水平减弱，对糖尿病的正常水平对糖尿病的影响造成了对培养的效果，并在培养的情况下效应了效应和效应。由于6-shogaol阻止了STZ引起的应力的损害。

结论： 6-Shogaol可以用作治疗剂，以防止糖尿病患者的并发症。糖尿病治疗将6-肖乳视为药物疗法或与草药植物或其他6-shogaol的组合药物可能是一种很好的治疗药物，因为它不仅涵盖了胰腺β细胞，还涵盖肝脏和肾脏。生姜可能是理想的，因为它们包含各种具有不同已知药理作用的药理学化合物。