Origanum Majorana L.提取物对急性感染性腹泻的主要机制表现出积极的合作作用。
摘要来源：
j ethnopharmacol。 2019年7月15日； 239：111503。 EPUB 2018年9月11日。PMID： 30217790“> 30217790 Mekhfi, Abderrahim Ziyyat, Abdelkhaleq Legssyer, Ahmed Melhaoui, Mohamed Berrabah, Mohamed Bnouham, Chakib Alem, Ferdinand Kouoh Elombo, Bernard Gressier, Jehan-François Desjeux, Bruno Eto
Article Affiliation:Hanane makrane
摘要：
族裔药理学相关性： oildanum majora majorana L.（lamiaceae）通常用于摩洛哥民间医学，用于治疗婴儿绞痛，腹部的不适和诊断。急性感染性腹泻中观察到的液体粪便和腹部不适是INTE之间不平衡的后果stinal water secretion and absorption in the lumen, and relaxation of smooth muscle surrounding the intestinal mucosa.
AIM OF THE STUDY: The objective of our study was to see if aqueous extract of Origanum majorana L. (AEOM) may exhibit an effect on those deleterious mechanisms.
MATERIALS AND METHODS: The effect of AEOM on electrogenic Clsecretion and Naabsorption, the two main mechanisms underlying water movement in the intestine, was assessed on intestinal pieces of mice intestine mounted, in vitro, in Ussing chambers. AEOM effect on muscle relaxation was measured on rat intestinal smooth muscle mounted in an isotonic transducer.
RESULTS: 1) AEOM placed on the serosal (i.e. blood) side of the piece of jejunum entirely inhibited in a concentration-dependent manner the Forskolin-induced电氯秒返回，IC = 654±8µg/ml。 2）将AEOM放在粘膜（即腔内）侧面，以浓度依赖性的方式刺激了电源NAABSSARTINIT，IC = 476.9±1µg/ml。 3）AEOM（1mg/ml）抑制福斯科蛋白诱导的电源分泌几乎通过事先暴露于光纳尔或神经递质抑制剂的情况下完全阻止了。 4）回肠中的AEOM（1mg/ml）促进作用更大，在空肠，远端结肠和近端结肠（最小）中逐渐下降。 5）AEOM以浓度依赖性的方式抑制平滑肌卡巴乔尔或KCL诱导的收缩，分别为1.64±0.2mg/ml或1.92±0.8mg/ml。 L.对急性感染性腹泻的主要机制表现出积极的合作作用。