摘要来源： dig dig dis sci。 2012年1月； 57（1）：99-108。 EPUB 2011年7月12日。PMID： 21748285 21748285
aixia ren
摘要：
METHODS: Cesinex(®) was prescribed to six children and four adults with diarrhea. Patient records were retrospectively reviewed for the primary outcome. Cesinex(®) and its major component, tannic acid, were tested for their effects on cholera toxin-induced intestinal fluid secretion in mice. Polarized human gut epithelial cells (HT29-CL19A cells) were used to investigate the effects of tannic acid on epithelial barrier properties, transepithelial chloride secretion, and cell viability.
RESULTS: Successful resolution of diarrheal symptoms was reported in nine of ten patients receiving Cesinex(®).用临床相关的单宁酸（0.01-1 mg/ml）处理HT29-CL19A细胞，显着增加了旋转的替代性（TER），并抑制囊性纤维化跨膜电导量调节剂（CFTR） - 依赖或依赖的cl（CFTR）还改善了由肿瘤坏死因子α（TNFα）诱导的上皮屏障功能受损，并抑制了TNFα对这些细胞上皮屏障功能的破坏作用。霍乱毒素（CTX）诱导的小鼠肠道液体分泌显着降低了cesinex（®）或单宁酸。 cesinex（®）具有高抗氧化能力。
结论： cesinex（®）表现出功效和良好的腹泻治疗安全性。 cesinex（®）的广谱抗抗虫效应可以归因于多种因素的组合：它改善上皮屏障特性，抑制肠道液体的分泌能力和高抗氧化剂的能力。