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Abstract Title:Probiotic: Effective for Managing Childhood Diarrhea by Altering Gut Microbiota and Attenuating Fecal Inflammatory标记。
摘要来源:
营养。 2019年5月23日; 11(5)。 EPUB 2019年5月23日。PMID: 31126062“> 31126062 Kong,Chee-Jen Chang,Chien-Chang Chen
文章隶属关系:Hung-Hsiang lai
摘要:
背景: 急性诊断>急性腹泻是儿童疾病的主要原因和家庭经济损失的主要原因和家庭的经济率和家庭的经济负担。这项研究的目的是探索益生菌对儿童腹泻期间临床症状,肠道菌群和炎症标志物的影响。
methoDS: 儿童(= 81)年龄六个月至六岁(平均年龄2.31岁)住院治疗急性腹泻,以随机接受益生菌(品种; = 42)或无益生菌(= 39),每天两次口服两次。还收集了粪便样品,以使用传统的琼脂板和下一代测序评估微生物含量。免疫球蛋白A(IgA),乳铁蛋白和钙染色蛋白通过酶联免疫吸附测定法(ELISA)确定,并在不同组中进行比较。 Other clinical symptoms or signs, including fever, vomiting, diarrhea, abdominal pain, bloated abdomen, daily intake, appetite, and body weight were also assessed.
RESULTS: Data were collected from 81 individuals across three different time points.益生菌组的粪便提取物中的粪便总IgA水平高于对照组中的粪便,具有统计显着性(0.05)。粪便乳铁蛋白的浓度与对照组相比,益生菌(LC)的患者(LC)患者的钙染色蛋白和钙特染色素显着下调(0.05)。益生菌LC给药可能对肠道微生物群调节有益,如入学后一周收集的数据所示。在益生菌组的粪便培养中,种类和种类的数量升高。 Appetite and oral intake, body-weight gain, abdominal pain, bloating, as well as bowel habits (diarrhea) were much better in children receiving probiotics compared with those in the control group.
CONCLUSION: Fecal IgA increased during acute diarrhea under Lc treatment;相反,在LC处理下,急性腹泻期间粪便乳铁蛋白和钙染色素被下调。益生菌LC可能是在急性腹泻期间在儿童中应用以降低临床严重程度和肠炎症反应的有用补充。