石榴汁对大鼠模型中甲氨蝶呤诱导的肠道损伤后肠道恢复的影响。
摘要来源：
j am coll Nutr。 2018年3月13日：1-9。 EPUB 2018 3月13日。PMID： 29533141“> 29533141 Schwartz, Yulia Pollak, Igor Sukhotnik
Article Affiliation:Ron Shaoul
Abstract:BACKGROUND/AIMS: Several studies have demonstrated the antimicrobial, antihelminthic, and antioxidant potential of the active ingredients of pomegranate （PMG）提取物，表明它们在几种胃肠道疾病中的预防和治愈作用。在本研究中，作者评估了补充口服PMG对甲氨蝶呤（MTX）诱导的大鼠肠损伤期间肠结构变化，肠细胞增殖和凋亡的影响。
方法： 雄性大鼠分为4个实验组：对照大鼠；在注射前72小时和72小时后，用口服PMG治疗CONTH-PMG大鼠。 MTX大鼠用单剂量的甲氨蝶呤处理；注射MTX后，用口服PMG处理MTX-PMG大鼠。 MTX注射后72小时确定肠粘膜损伤，粘膜结构变化，肠细胞增殖和肠细胞凋亡。 Western blotting was used to determine phosphorylated extracellular signal-regulated kinase (p-ERK) and caspase 3 protein levels.
RESULTS: MTX-PMG rats demonstrated greater jejunal and ileal bowel and mucosal weights, greater jejunal and ileal mucosal与MTX动物相比，在空肠和回肠中的绒毛和蛋白质水平更高，回肠的隐窝深度。 EN显着下降terocyte apoptosis in ileum of MTX-PMG rats (vs MTX) was associated with a decrease in caspase 3 protein expression as well as increased cell proliferation, which was correlated with elevated p-ERK protein levels.
CONCLUSIONS: Treatment with oral PMG prevents mucosal injury并改善大鼠MTX损伤后的肠道恢复。