Naringin可能会成为治疗和预防NSAID相关肠道疾病的新方法

NARINGIN对NSAID相关肠病中小肠损伤的保护作用，通过调节ghrelin/ghs-r信号传导途径。

life sci。 2020年12月15日； 266：118909。 EPUB 2020 12月15日。PMID： 33333047“> 33333047 zhang

guanqun chao

目标： 研究ghrelin/ghs-r信号途径在NSAIDS相关的小肠中诱导的小肠损伤的机制。用Naringin用Naringin作为一种新的治疗方法来阐明肠粘膜修复的机制网络。

方法： naringin用作干预方法，观察到小肠子和ghs ghs ghs ghs ghs ghs ghr r r r r r r r r r r r r r r r r r r r r r r r r r r r r r r r r r in MICROSCOpy, HE staining and immunohistochemistry.

RESULTS: Compared with the control group, the weight of rats in the model group decreased, the thickness of intestinal mucosa became thinner, the structure of intestinal mucosa changed, the expression of ghrelin, GHS-R and leptin decreased, the expression of TNF-α增加。 Compared with the model group, the intestinal mucosa of the treatment group was repaired, the expression of ghrelin, GHS-R and leptin was increased, and the expression TNF-α was decreased.

CONCLUSION: The mechanism of intestinal mucosal damage in patients with NSAIDs related enteropathy may be related to the降低生长素蛋白，GHS-R和瘦素的表达以及TNF-α分泌的促进。纳林蛋白可以有效地促进生长素蛋白和瘦素的分泌，GSH-R的表达并抑制TNF-α的释放，以修复肠粘膜粘膜。将成为一种治疗和预防NSAID相关的肠道疾病的新方法。