抽象来源: 摩尔自闭症。 2018; 9:61。 EPUB 2018 12月10日。PMID: 305555669“> 305555669 Hull, Robert W Li, Verónica Martínez-Cerdeño Fang Liu Background: Gut microbiota has the capacity to impact the regular function of the brain, which can in turn affect the composition of microbiota.自闭症谱系障碍(ASD)患者患有胃肠道问题并经历肠道菌群的变化;但是,尚不清楚微生物群的变化是否与ASD相关的是该疾病的原因或结果。 方法: 我们已经研究了丙乳酸(VPA)诱导的大鼠大鼠模型自闭症中的物种丰富度和微生物组成。从直肠上收集来自直肠的粪便样品,在尸检,提取微生物总DNA,使用Illumina测序的16个RRNA基因,并使用基于随机基质理论的管道构建了全局微生物共发生网络。 Collected rat microbiome data were compared to available data derived from cases of autism. Results: We found that VPA administration during pregnancy reduced fecal microbial richness, changed the gut microbial composition, and altered the metabolite potential of the fecal microbial community in a pattern similar to that seen in patients with ASD。但是,全球网络属性和网络组成以及微生物共发生PAT燕鸥在暴露于VPA产前给药的大鼠的后代中。模仿自闭症的微生物组特征,使其成为研究自闭症和ASD的最佳啮齿动物模型之一