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Abstract Title:The altered gut microbiota in adults with cystic fibrosis.
Abstract Source:
BMC微生物。 2017年3月9日； 17（1）：58。 EPUB 2017 3月9日。PMID： 28279152“> 28279152 P D Cotter, O OSullivan, C Stanton, C Hill, F Shanahan, B J Plant, R P Ross
Article Affiliation:D G Burke
Abstract:BACKGROUND: Cystic Fibrosis (CF) is an autosomal recessive disease that affects the function of a number of器官，主要是肺部，也是胃肠道。胃肠道中囊性纤维化跨膜电导调节剂（CFTR）功能障碍的表现以及频繁的抗生素EX姿势，无疑会破坏肠道菌群。为了分析CF及其管理对微生物组的影响，我们使用16S rRNA基因的454-Pyrosequencing比较了稳定性期间43个CF个体的肠道菌群。 The impact of clinical parameters, including antibiotic therapy, on the results was also assessed.
RESULTS: The CF-associated microbiome had reduced microbial diversity, an increase in Firmicutes and a reduction in Bacteroidetes compared to the non-CF controls.虽然在CF和健康对照组之间观察到肠道菌群的分类学丰度的最大差异，但在CF中，CF的肠道菌群差异也有所报道，当时CF的患者是通过临床参数分组的，包括临床参数，包括％预测的FEV1（肺功能障碍的度量）和前一个静脉内的抗腹膜尿布菌的数量。ths。值得注意的是，相对于患有轻度或中度功能障碍的患者，患有严重肺功能障碍（预测FEV1≤40％）的CF个体显着（P <0.05）降低了肠道菌群多样性。 A significant negative correlation (-0.383, Simpsons Diversity Index) was also observed between the number of IV antibiotic courses and gut microbiota diversity.
CONCLUSIONS: This is one of the largest single-centre studies on gut microbiota in stable adults with CF and demonstrates the与健康对照组相比，CF患者的微生物多样性降低了肠道微生物群，包括降低的微生物多样性。数据显示了CF及其管理对肠道微生物群的影响，这是有机会开发CF特定益生菌以最大程度地减少微生物群的改变。