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Abstract Title:The inhibitory effects of polysaccharide peptides (PsP) of Ganoderma lucidum against血脂异常大鼠的动脉粥样硬化。
抽象来源:
心脏int。 2017年1月至12月; 12(1):E1-E7。 EPUB 2017 4月12日。PMID: 29114382 29114382 Heriansyah
文章隶属关系:titin andri wihastuti
摘要:
目标:> level, IL-10 level, and EPC number in blood serum, and also intima-media thickness of aorta in dyslipidemia Wistar rat model by giving them a hypercholesterol diet (HCD).
Materials and methods: The study was an experimental in vivo post-test with control group design. Thirty-five Wistar rats (Rattus norwegicus) were divided into five groups (normal diet group, HCD group, and hypercholesterol groups that received 50 mg/kg, 150 mg/kg, and 300 mg/kg bodyweight PsP).
Results: Each treatment group showed significant results for管理PSP使用降低H2O2(p = 0.003)的单向方差测试分析(P <0.050),IL-10水平(P = 0.027),血清中EPC的数量(P = 0.011)和主动脉厚度(P = 0.000)。来自G. lucidum的PSP是一种有效的抗氧化剂,可能会阻止血脂异常患者的动脉粥样硬化过程。
结论: 这项研究中PSP的最佳剂量是300 mg/kg/kg bodyweigh。需要进一步的研究来确定PSP G. lucidum的抗氧化作用及其在血脂异常的治疗中的益处。