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Abstract Title:Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ诱导的糖尿病大鼠。
摘要来源：
int j vasc Med。 2018; 2018：6428630。 EPUB 2018 1月28日。PMID： 29796316“> 29796316 Barbanera，NágillaOrleannelima do Carmo，Lucas Rodolfo de Oliveira Rosa，AnaAngélicaHenriquefernandes
文章隶属关系：Anderson Kiyoshi Kaga
摘要：
（T1DM）的特征是胰岛素缺陷的产生导致高血糖，这与糖尿病并发症（如心血管疾病）有关。抗氧化剂已证明是D的良好替代品iAcety并发症，具有抗氧化剂特征的N-乙酰半胱氨酸（NAC）。 The aim of this study was to assess the effect of NAC on the lipid profile and the atherogenic index (AI) in streptozotocin- (STZ-) induced diabetic rats.
Method: 32 male Wistar rats (60 days of age) weighting±250 g were randomly distributed into four groups （= 8）：CTRL：控制大鼠； CTRL+NAC：用NAC处理的对照大鼠； DM：糖尿病大鼠； DM+NAC：用NAC处理的糖尿病大鼠。使用STZ（60 mg/kg，IP;单剂量）和NAC（25 mg/kg/day）诱导T1DM，用Gavage管理37天。动物收到了盘子和水。 After the experimental period, blood and cardiac tissue samples were collected to analyze energetic metabolism, lipid profile, and AI.
Results: NAC decreased (<0.01) glycemia, energy intake, carbohydrate, and protein consumption in diabetic rats (DM+N与DM相比，AC），而治疗的糖尿病大鼠（DM+NAC）的消化效率提高（<0.01）。与DM相比，用NAC处理的糖尿病大鼠糖尿病大鼠（DM+NAC）的糖尿病大鼠减少（<0.01）脂质谱和AI。大鼠。