烟酸水平高的食物消费可能有助于预防或延迟血脂异常的发作

BACKGROUND & AIMS: Although the pharmacological effect of niacin in lowering blood cholesterol and triglyceride levels has been demonstrated in several clinical studies, information regarding the effect of dietary niacin intake is uncertain, and the longitudinal association between dietary niacin intake and the risk血脂异常的血症尚未达到ADEQ

方法： 我们分析了韩国三项基于社区的队列研究的数据，其中包括211,567名参与者，年龄≥40岁。使用经过验证的半定量食品频率问卷估算饮食烟酸的摄入量，并在随访期间通过调查确认血脂异常的发生。 We applied Cox proportional hazard regression to calculate the cohort-specific hazard ratio (HR) and 95% confidence interval (CI) for dyslipidemia and pooled the results using the fixed-effects method.

RESULTS: Higher dietary niacin intake was associated with a reduced risk of血脂异常（合并，多变量调整的HR：0.71，95％CI：0.62-0.82）。与饮食中烟酸摄入量高于韩国建议的饮食津贴的群体相比，血脂异常的风险增加了32％（合并，多变量调整后的HR：1.32，95％CI：1.19-1.46）在低于韩国估计平均要求的组中。 Spline regression showed a dose-response linear relationship between dietary niacin intake and the risk of dyslipidemia (all p-values for nonlinearity>0.05).

CONCLUSION: Consumption of foods with high niacin levels may help prevent or delay the onset of血脂异常。