摘要来源： bmc补体med ther。 2022年1月22日； 22（1）：19。 EPUB 2022 1月22日。PMID： 35065636“> 35065636 Ladan Rahmani，Zahra Majidi，Gordon A Ferns，Afsane Bahrami Leyla Arabnezhad 背景：背景： vidamin d具有女性重现。还有证据表明，维生素D水平与月经问题（如经前综合征（PMS）和痛经性）之间存在关联。姜黄素是一种生物活性多酚姜黄的组成，可能与维生素D受体及其分子靶标相互作用。 This study evaluated the effects of curcumin on vitamin D levels in young women with PMS and dysmenorrhea. METHODS: In this randomized, triple-blind, placebo-controlled trial, women with PMS and dysmenorrhea were divided randomly into experimental and control groups to receive one capsule （500毫克的姜黄素+5 mg胡须蛋白或安慰剂），从大约7天之前，直到月经后3天连续三个连续的月经周期。在干预之前和之后还测量了血清维生素D水平，肾功能和肝酶。 结果： 总共76名受试者（38个组中的38名受试者）被招募到试验中。姜黄素显着提高了维生素D的中值（IQR）血清水平[从12.8 ng/ml（7.0-24.6）到16.2 ng/ml（6.4-28.8）; p = 0.045]，与安慰剂[从18.6 ng/ml（2.2-26.8）到21.3 ng/ml（5.2-27.1）; p = 0.17]。在姜黄素组的试验结束时，天冬氨酸氨基转移酶和直接胆红素的血清水平降低（p <0.05），但在对照组中没有显着变化（p> 0.05）。 Finally, no significant differences in levels of fasting blood glucose were detected between curcumin and placebo groups. CONCLUSION: Curcumin supplementation in women with PMS and dysmenorrhea led to a significant improvement of vitamin D, liver function enzyme test, but did not affect blood glucose. TRIAL REGISTRATION: The trial was registered on Iranian Registry of Clinical Trials registry (Trial ID: IRCT20191112045424N1 on 23 January 2020; available at https://www.irct.ir ).