海buckthorn（HippophaëRhamnoidesL.）油通过抑制NF-κB和STAT1激活来改善特应性皮炎的皮肤病变。
抽象来源：
皮肤药物。 2017; 30（5）：268-276。 EPUB 2017年9月6日。PMID： 28873377 28873377 Qi, He-Xiao Wang, Song Zheng, Yu-Xiao Hong, Hao Guo, Hong-Duo Chen, Xing-Hua Gao
Article Affiliation:Dian-Dong Hou
Abstract:BACKGROUND AND OBJECTIVES: The objective of this study was to evaluate the topical effects of sea buckthorn (SBT) oil on atopic dermatitis (AD)-like lesions in a mouse model generated by repeated topical administration of DNCB in BALB/c mice.
METHODS: DNCB was applied repeatedly on the dorsal skin of mice to induce AD-like lesions. fo每天在背皮上施用SBT油，持续4周。在宏观和组织学上检查了皮肤病变的严重程度。 We further measured the production of MDC/CCL22 and TARC/CCL17 in IFN-γ/TNF-α activated HaCaT cells.
RESULTS: Topically applied SBT oil in DNCB-treated mice ameliorated the severity score of dermatitis, decreased epidermal厚度，脾脏减少和淋巴结的重量，并防止肥大细胞浸润。此外，SBT油通过剂量依赖性抑制NF-κB，JAK2/STAT1和p38-MAPK信号通路抑制TH2趋化因子TARC和MDC，IFN-γ/TNF-α-激活HACAT的HACAT细胞。 SBT油对类似AD的皮肤病变具有有益的作用，部分是通过抑制发炎的皮肤中Th2趋化因子TARC和MDC的。