糖酸通过调节免疫平衡来抑制特应性皮炎的症状

Dian-Dong Hou

BACKGROUND: Glycyrrhiza is one of the most widely used traditional Chinese中国的药物。 Its main bioactive ingredient glycyrrhizic acid (GA) has the potential to be used as a treatment for atopic dermatitis (AD) because it has similar actions to steroids, but with relatively few side effects.

AIMS: The objective of this study was to explore the potential mechanisms of GA on AD mice模型。

方法： 钙蛋白D3模拟（MC903）局部应用以建立AD鼠标模型。用2 mg/kg地塞米松（DEX），25或50 mg/kg ga腹膜内治疗小鼠15天。执行小鼠后，收集皮肤组织并检测到IL-4，IFN-γ，TNF-α和胸腺基质淋巴细胞增多素（TSLP）的表达水平。 The percentages of Th1, Th2, Th17, langerhans cells (LCs) in draining lymph nodes(dLNs) were measured by flow cytometry.

RESULTS: Our data demonstrated that GA improved the symptoms of AD by exerting anti-inflammatory and anti-allergic functions in体内。我们发现GA治疗降低了血清中IgE的总IgE水平，抑制耳朵肿胀，减少了皮肤病变中肥大细胞的浸润，并降低了IL-4，IFN-γ，TNF-α和TSLP的表达。此外，我们的实验结果表明GA抑制了DLN中的Th1/Th2/Th17-免疫反应，抑制了DLNS中LC的迁移。

结论： 在结论中，我们的发现建议对MC903-造成的效果。小鼠。