Click here to read the complete article.
Abstract Title:Anti-inflammatory effects of Morus alba Linne bark on the activation of toll-like receptors and咪喹莫德诱导的小鼠耳水肿。
摘要来源:
bmc补体med ther。 2021年4月9日; 21(1):115。 EPUB 2021 4月9日。PMID: 33836731“> 33836731 Kasahara, Dya Fita Dibwe, Suresh Awale, Satoru Yokoyama, Yoshihiro Hayakawa
Article Affiliation:Lin Umeyama
Abstract:BACKGROUND: Morus alba L. bark has been widely used in traditional medicine for treating several inflammatory diseases, such as高血压,糖尿病和咳嗽;但是,其抗炎作用AR的分子机制ARe not well understood.
METHODS: We examined the effects of an extract of Morus alba L. bark (MabE) on Toll-like receptor (TLR) ligand-induced activation of RAW264.7 macrophages using a luciferase reporter assay and immunoassays.对于体内实验,我们使用了咪喹莫夫诱导的耳水肿模型来检查mabe的抗炎作用。
结果: mabe抑制了tlr tlr tlr tlr tlr诱导的nf-2644.的抗炎。与NF-κB激活的抑制一致,MABE还抑制了TLR配体处理的RAW264.7细胞的IL-6和IL-1β的产生。除了IL-17a,IL-1β和COX-2的mRNA表达外,体内MABE处理还抑制了IMQ处理的小鼠的耳朵肿胀。 IMQ处理的小鼠中脾γδT细胞的增加,并从脾细胞中产生IL-17a的产生。y mabe治疗。
结论: