尿石蛋白A对血管内皮功能改善的影响取决于肠道微生物群

摘要来源：

正面营养。 2022; 9：1077534。 EPUB 2023 JAN 5。PMID： 36687672 36687672 富士岛，乌木瓦，马萨塔克·库多（Masatake kudoh肠道菌群从摄入的椭圆酸产生的代谢产物。尽管已经报道了椭圆酸摄入对血管内皮功能（VEF）改善的影响，但UA摄入对VEF改善的影响仍然晦涩难懂。另外，UAhas been reported to improve the intestinal barrier function, and UA may have improved VEF by gut microbiome alteration.

OBJECTIVE: In this study, we conducted a clinical trial to explore and analyze the effects of UA intake on vascular endothelial function (VEF) and characteristics of the intestinal environment, such as gut microbiome profiling and organic acid composition.

METHODS: A placebo-controlled, randomized, double-blinded, parallel group trial was conducted on participants who could metabolize small amounts of UA from ellagic acid (non-UA producers) and had relatively poor VEF.使用流介导的血管舒张（FMD）评分评估VEF。将参与者服用安慰剂，UA 10毫克/天或50毫克/天UA，持续12周。测量FMD，并在0、4、8和12周的治疗中收集粪便样品。肠道微生物组分析和有机酸液液进行L测量以评估UA摄入对肠道环境的影响。该临床试验在UMIN-CTR上公开注册，试验编号：UMIN000042014。