摘要标题：
afternation-per a narring flav per per per per per per per per per per per per per per per per per per per per per per per per per per per per per per per per pen小鼠的癫痫症和氧化应激。
摘要来源：
PharmaCogn Mag。 2017年1月; 13（增刊1）：S154-S160。 EPUB 2017 4月7日。PMID： 28479741 28479741 Tabassum，Umar Amin，Manzoor ur rahman mir
文章隶属关系：Sheeba Shakeel
摘要：
背景： 癫痫发作是复发性癫痫发作的中枢神经系统的混乱。这是一种非常常见的疾病，其中大约30％的患者对抗惊厥药的治疗没有反应。氧化应激与神经元达马有关由癫痫发作引起的。本研究研究了纳林宁蛋白在小鼠毛果石诱导的癫痫中的影响。 Naringenin, one of the most frequently occurring flavanone in citrus fruits, was evaluated for its shielding effect against the pilocarpine induced behavioural, oxidative and histopathological alterations in rodent model of epilepsy.
METHODOLOGY: Epilepsy was induced by giving pilocarpine （300mg/kg）和丙丙酸钠（300mg/kg）作为标准的抗癫痫性药物毛Pilocarpine（300 mg/kg体重）在小鼠腹膜内（300 mg/kg体重）在15天内腹膜内腹膜内，而Naringenin则在口头上服用20和40 mg/kg体重（20和40 mg/kg体重） Pilocarpine。
结果： 毛car的腹膜内给药pilocarpine增强的脂质过氧化，导致抗氧化酶的降低e歧化酶和谷胱甘肽还原酶。用Naringenin（20 mg/kg体重和40 mg/kg体重）口服小鼠的小鼠可显着降低脂质过氧化。谷胱甘肽含量和所研究的所有抗氧化剂酶都有显着恢复。同样在研究行为参数的情况下，纳林宁蛋白显示出癫痫发作严重程度的降低。 All these changes were supported by histological observations, which revealed excellent improvement in neuronal damage.
CONCLUSION: The higher dose of naringenin was more potent in our study and was comparable to the standard drug (sodium valproate) in effectiveness.
摘要： naringenin改善了河马中ROS形成的发展。纳林宁蛋白有助于恢复抗氧化剂酶。纳林宁降低了癫痫发作。癫痫发作降低了癫痫发作。使用的缩写: 6-OHDA: 6-hydroxydopamine, AED: Anti epileptic drugs, AIDS: Acquired immune deficiency syndrome, ANOVA: Analysis of variance, ATP: Adenosine triphosphate, CA: Cornu ammonis, CAT: Catalase, DG: Dentate gyrus, EDTA: Ethylenediamine tetra acetic acid, GR: Glutathione reductase, GSH: Glutathione reduced, HCl: Hydrochloric acid, IL-1β: Interleukin 1 beta, LPO: Lipid peroxidation, MDA: Malondialdehyde, NADPH: Nicotinamide adenine dinucleotide phosphate, PMS: post mitochondrial supernatant, SE: Status epilepticus, SEM: Standard error of the mean, SOD Superoxide歧义酶，TBA：硫巴比妥酸，TBAR：硫巴比妥酸反应性物质，TLE：颞叶癫痫，TNF-α：肿瘤坏死因子alpha。